Sudden Death in Epilepsy Plunges With Drug Treatment

By Joyce Frieden — From medpagetoday.com Published at September 22, 2011 Views 1,295 Likes 1

Epilepsy patients with previously uncontrolled seizures have a much lower rate of sudden death if they are given adjunctive anti-epilepsy drugs, a meta-analysis has found.
n an examination of 112 trials, the odds ratio for sudden unexpected death (SUDEP) in patients randomly assigned to anti-epileptic drugs (AEDs) at efficacious doses versus those assigned to placebo was 0.17 (95% CI 0.05 to 0.57, P=0ยท0046), Philippe Ryvlin, MD, of Hospices Civils de Lyon in France, and colleagues reported online in The Lancet Neurology.
"To the best of our knowledge, this post-hoc analysis offers the first controlled evidence that an intervention may modify the risk of SUDEP," the authors wrote. "The more than seven-fold difference in SUDEP incidence noted between patients randomly assigned to placebo and those receiving AEDs at efficacious doses points to a significant finding with magnitude that cannot be ignored."

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