Anti-Epileptic Drug Exposure During Pregnancy Increases Risk of Major Congenital Malformations

By Thomas S. May — From Published at July 26, 2010 Views 1,638

Two major studies presented here on June 28 during a platform session on drug therapy at the 9th European Congress on Epileptology (ECE) have found that several anti-epileptic drugs (AEDs) are associated with major congenital malformations (MCMs) in the offspring of women taking AEDs during pregnancy.

One of the studies, EURAP (an international registry of antiepileptic drugs and pregnancy), assessed the comparative risk of major MCMs following exposure to AEDs during pregnancy. The researchers looked at pregnancy outcomes in over 5,000 pregnancies involving AEDs and recorded the number of MCMs at 12 months after birth.

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